Reproductive biology of PLCζ and its potential value in assisted reproductive technology

VernacularTitle:PLCζ的生殖生物学作用及其在辅助生殖中的潜在价值
Author: Tianying YANG ¹ ; Xiaoxi SUN ; Aijie XIN
Author Information

1. 复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心，上海　200011
Publication Type:Journal Article
Keywords: Reproductive techniques, assisted; Infertility, male; PLCζ; Oocyte activation
From: Chinese Journal of Reproduction and Contraception 2023;43(10):1079-1084
CountryChina
Language:Chinese
Abstract: Phospholipase Cζ (PLCζ) is composed of XY domain, EF-hand domains and a C2 domain, which specifically hydrolyzes phosphatidylinositol (4,5)-bisphosphate (PIP 2) in the oocyte cytoplasm but not on the plasma membrane through the classical PIP 2→(1,4,5)-inositol trisphosphate (IP 3)+diacylglycerol (DAG) signal transduction pathway, which causes oscillation of calcium ion in oocytes, and plays an irreplaceable role in activating oocytes and initiating gamete development. Clinical data have shown that the reduced or absent expression level of PLCζ can lead to the inability of sperm activating oocytes and are closely related to various sperm abnormalities, ultimately leading to male subfertility and even infertility. In summary, this article reviews the structure and biological functions of PLCζ, the clinical diseases caused by abnormal PLCζ and their following therapeutic progresses.