Effects of season on clinical outcomes of fresh embryo transfer
10.3760/cma.j.cn101441-20220701-00285
- VernacularTitle:季节对新鲜周期胚胎移植临床结局的影响
- Author:
Mingze DU
1
;
Junwei ZHANG
;
Yanli WU
;
Jing LIU
;
Yichun GUAN
Author Information
1. 郑州大学第三附属医院生殖医学科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Season;
Temperature;
Live birth rate;
Clinical pregnancy rate
- From:
Chinese Journal of Reproduction and Contraception
2023;43(10):1012-1017
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether there is an association between season, temperature, as well as cumulative sunlight exposure on the day of oocyte retrieval and clinical outcomes of in vitro fertilization (IVF) and fresh embryo transfer. Methods:It was a retrospective cohort study, including patients who underwent IVF in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from August 2015 to October 2019. They were divided into four groups according to the oocyte retrieval date. Spring group: the oocyte retrieval date was from March to May. Summer group: the date of oocyte retrieval was from June to August. Autumn group: the date of oocyte retrieval was from September to November. Winter group: the date of oocyte retrieval was from December to February of the next year. The main outcome measures were clinical pregnancy rate and live birth rate. Binary logistic regression was used to explore the factors affecting clinical pregnancy rate and live birth rate.Results:There were no significant differences in the miscarriage rate and the live birth rate among the four groups (all P>0.05). The pairwise comparison between the groups indicated that the clinical pregnancy rate in the winter group [56.9% (816/1 435)] was lower than that in the summer group [61.5% (1 359/2 210), P=0.005]. Taking winter as the reference, the clinical pregnancy rate in summer was higher (a OR=1.25, 95% CI: 1.09-1.44, P=0.002). The clinical pregnancy rate in spring (a OR=1.14, 95% CI: 0.99-1.32, P=0.073) and autumn (a OR=1.09, 95% CI: 0.94-1.26, P=0.254) was not significantly different from winter. Binary logistic regression analysis showed that higher mean temperature was associated with higher clinical pregnancy rate (a OR=1.01, 95% CI: 1.00-1.01, P=0.005). Season, temperature and cumulative sunshine on the day of egg retrieval had no significant effect on the live birth rate. Conclusion:Summer and high temperature are independent and favorable influencing factors of clinical pregnancy rate. However, different seasons, temperatures and cumulative sunshine had no significant effect on live birth rate.
