Metabolic Reprogramming in Pancreatic Cancer
10.13865/j.cnki.cjbmb.2025.06.1523
- VernacularTitle:代谢重塑驱动胰腺癌发生发展的作用机制
- Author:
Yi-Ni XU
1
;
Ji-Yun ZHU
;
Si-Ming ZHENG
Author Information
1. 浙江大学医学院附属第一医院肝胆胰外科,杭州 310000
- Publication Type:Journal Article
- Keywords:
pancreatic cancer(PC);
metabolic reprogramming;
glucose metabolism;
fatty acid metab-olism;
amino acid metabolism
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(8):1149-1158
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a malignant tumor with a very poor prognosis,characterized by early me-tastasis and high invasiveness,and is unresponsive to traditional treatments like chemotherapy and radio-therapy.In recent years,the study of metabolic products has become a new hotspot in pancreatic cancer research,showing that the metabolic reprogramming of tumor cells is a key factor for their growth and pro-liferation,and that regulatory factors of metabolic pathways may serve as new therapeutic targets.Meta-bolic reprogramming primarily manifests as alterations in three major nutrient metabolic pathway and oxi-dative phosphorylation processes.Additionally,the tumor microenvironment of pancreatic cancer exhibits unique metabolic features.Mechanistic studies are actively underway,and future research may focus on integrating omics,artificial intelligence,and other novel research techniques to further explore how meta-bolic changes drive the development of pancreatic cancer and to improve treatment strategies,including the development of targeted drugs and metabolomics-based diagnostic tools.
