The Expression and Clinical Significance of PHB2 in Diabetic Kidney Disease
10.13241/j.cnki.pmb.2025.13.006
- VernacularTitle:PHB2在糖尿病肾病中的表达及临床意义
- Author:
Wei-min ZHAO
1
;
Qi AO
;
Bin WU
;
Cai-hua LIE
Author Information
1. 石河子大学医学院 新疆石河子 832000
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Prohibitin 2;
Renal biopsy;
Immunohistochemistry
- From:
Progress in Modern Biomedicine
2025;25(13):2130-2137
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and clinical significance of Prohibitin 2(PHB2)in the kidney tissue of patients with Diabetic Kidney Disease(DKD).Methods:From March 2015 to May 2024,samples were collected from 16 patients diagnosed with diabetic nephropathy through renal biopsy,who met the inclusion criteria(referred to as the DKD group).Additionally,20 patients with renal tumors undergoing nephrectomy,who had partially normal kidney tissue,were selected to serve as the control group(NC group).The pathological changes of the two groups of samples were evaluated by HE and PAS staining.Immunohistochemistry was utilized to analyze the differences in PHB2 protein expression between the two groups.Pearson or Spearman correlation methods were applied for statistical analysis.Results:PHB2 was expressed in renal tubules,and its expression level in the diabetic kidney disease(DKD)group was significantly lower than that in the normal control(NC)group(P＜0.05).Additionally,the expression level of PHB2 in diabetic nephropathy was found to be negatively correlated with glycated hemoglobin,serum creatinine,cystatin C,and blood urea nitrogen(P＜0.05).In contrast,there was a positive correlation between PHB2 expression and the estimated glomerular filtration rate(eGFR)(P＜0.05).Therefore,PHB2 expression serves as a negative correlation factor for serum creatinine,cystatin C,and blood urea nitrogen,while being a positive correlation factor for eGFR.Conclusions:In patients with diabetic nephropathy,the expression of PHB2 in renal tissue significantly decreases.This reduction in PHB2 levels closely correlates with glucose metabolism and renal function.Low levels of PHB2 may worsen glucose metabolism disorders,renal function damage,and proteinuria.Therefore,PHB2 serves as a potential biomarker for assessing prognosis and offers new insights into the treatment of diabetic kidney disease.
