The medication patterns and potential mechanisms of Chinese medicine in the treatment of oral ulcers studied by data mining and network pharmacology
10.3969/j.issn.1001-3733.2025.01.008
- VernacularTitle:基于数据挖掘和网络药理学探讨口疮治疗的中医用药规律及潜在作用机制
- Author:
Yuanyuan YI
1
;
Ping ZHANG
;
Jun YUAN
Author Information
1. 430065 武汉,湖北中医药大学中医学院
- Publication Type:Journal Article
- Keywords:
Mouth ulcers;
Data mining;
Network pharmacology;
Medication patterns;
Mechanism of action
- From:
Journal of Practical Stomatology
2025;41(1):52-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the prescription and medication patterns of traditional Chinese medicine for treating oral ulcers,and to explore the mechanism of the action of core drug combinations.Methods:The relevant literature in China Knowledge Network(CNKI),Wipro Chinese Journals(VIP),Wanfang Data(Wanfang)and Chinese Biomedical Literature(CBM)were searched and screened,EXCEL software was used to establish a database of traditional Chinese medicines compounded for the treatment of aph-thous stomatitis,the screened traditional Chinese medicines were analyzed in terms of frequency statistics,association rules,and studied by clustering analysis.The active ingredients,targets,and related pathways of core drug combinations for treating oral ulcers were studied by TCMSP,GeneCards,STRING,DAVID databases and Cytoscape software.Results:A total of 548 articles met the screening criteria,involving 368 traditional Chinese medicines.34 high-frequency drugs were found in more than 100 studies,with the majority of heat clearing and deficiency tonifying drugs.The drugs were mainly cold and bitter,the meridians of the liver and lung were more common.Further analysis revealed that the core drug combination with the highest support and confidence was"lico-rice-baicalin-huanglian".Network pharmacology analysis of"licorice-baicalin-huanglian"revealed that its main active ingredients were quercetin,kaempferol and wogonin,while AKT1,IL6,TNF,TP53,and IL1 β,JUN and others were the key core targets.KEGG pathway enrichment analysis revealed that it mainly involved cancer signaling pathway,NF-κB,PI3K-Akt,MAPK and JAK-STAT signaling pathway,etc.Conclusion:The prescription of traditional Chinese medicine for treating oral ulcers mainly focuses on tonifying qi and stomach,relieving pain and lowering bitterness.The combination of"licorice-huangqin-huanglian"medicine is im-portant in the treatment of oral ulcers.
