Advances in the genetic researches of human sperm morphological abnormality and teratozoospermia
10.3760/cma.j.cn101441-20221206-00546
- VernacularTitle:精子形态学异常的遗传学研究进展
- Author:
Fan DONG
1
;
Xiangfeng CHEN
1
Author Information
1. 上海交通大学医学院附属仁济医院生殖医学中心，上海 200135
- Publication Type:Journal Article
- Keywords:
Infertility, male;
Teratozoospermia;
Genetics;
Gene;
Chromosome;
Sperm morphology
- From:
Chinese Journal of Reproduction and Contraception
2023;43(5):461-467
- CountryChina
- Language:Chinese
-
Abstract:
Morphological abnormality of human sperm and teratozoospermia is one of the key causes of male infertility. With the progress of recent researches, more genetic causes were found to be involved in the pathogenesis of sperm morphological abnormality and teratozoospermia. This review analyzed the advances in genetic researches of human sperm morphological abnormality and teratozoospermia. We summarized the diagnosis of teratozoospermia, teratozoospermia-related genes, chromosomal abnormalities-related teratozoospermia as well as the reproductive outcomes of teratozoospermia. We also emphasized the relationship between genetic abnormalities and some special types of teratozoospermia, such as globozoospermia and multiple morphological abnormalities of the flagella (MMAF). We hope the article could give new genetic insight into the diagnosis, treatment and study of human sperm morphological abnormality and teratozoospermia.
