Research progress of pathogenesis and treatment of poor ovarian response

VernacularTitle:卵巢低反应的发病机制与治疗进展
Author: Xiaxuan ZHU ¹ ; Tian TIAN ¹ ; Rui YANG ¹
Author Information

1. 北京大学第三医院生殖医学中心，北京　100191
Publication Type:Journal Article
Keywords: Poor ovarian response; POSEIDON; Controlled ovarian stimulation; Gonadotrophin; Double ovarian stimulation
From: Chinese Journal of Reproduction and Contraception 2023;43(9):968-973
CountryChina
Language:Chinese
Abstract: As the proportion of women with advanced maternal age increases, the incidence of poor ovarian response (POR) has been higher. Meanwhile, POR has become one of the biggest challenges for reproductive experts on account of its association with a higher cancellation rate and a lower live birth rate. Different definitions of POR population were previously used, and patient heterogeneity caused inconvenience to clinical trials and practices. In 2016, a new classification by the Patient-Oriented Strategies Encompassing Individualized Oocyte Number (POSEIDON) group was introduced, providing a more detailed stratification of the POR, and bringing forward the concept of "low prognosis" to promote more standardized strategies in these patients. Evidence-based medicine has confirmed the effectiveness of several strategies, with more and more clinical trials including POR population stratified by POSEIDON. This article reviewed newly published researches, trying to provide decision support for POR management.