Purine Metabolism and Tumorigenesis
10.13241/j.cnki.pmb.2025.14.018
- VernacularTitle:嘌呤代谢与肿瘤发生
- Author:
Jia-hui WANG
1
;
Yue HUA
1
;
Ji-yong WANG
1
;
Xiao-qing GAN
1
Author Information
1. 复旦大学基础医学院代谢与分子医学教育部重点实验室 上海 200032
- Publication Type:Journal Article
- Keywords:
Purine metabolism;
Tumorigenesis;
Abnormal metabolism;
Targeted therapy
- From:
Progress in Modern Biomedicine
2025;25(14):2378-2390
- CountryChina
- Language:Chinese
-
Abstract:
Purine nucleotides,fundamental constituents of nucleic acids,represent essential organic molecules within cells.These molecules serve critical roles not only in nucleic acid biosynthesis,the transmission of genetic information and signal transduction cascades,but also function as precursors for the synthesis of energy substances.Consequently,purine metabolism is subject to stringent regulatory mechanisms that preserve cellular homeostasis and function integrity.Emerging evidence demonstrates that dysregulated purine metabolism exhibits significant associations with tumorigenesis and existing anti-tumor drugs have developed varying degrees of drugs resistance during therapy.Elucidating the mechanistic links between purine metabolic aberrations and tumorigenesis holds dual significance:it enhances our understanding of cancer pathophysiology while potentially informing novel therapeutic paradigms.This review systematically examines the pathophysiological contributions of key purine metabolic enzymes and intermediate metabolites to malignant transformation,while critically evaluating emerging anti-tumor strategies that target purine metabolism pathways.
