Enhancing the understanding of protein kinase fusion-related thyroid cancer
10.13315/j.cnki.cjcep.2025.01.002
- VernacularTitle:加强对蛋白激酶融合相关甲状腺癌的认识
- Author:
Jigang WANG
1
;
Zhiyan LIU
Author Information
1. 青岛大学附属医院病理科,青岛 266555
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
kinase fusion;
receptor tyrosine kinase;
targeted therapy
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(1):3-8
- CountryChina
- Language:Chinese
-
Abstract:
Significant advancements have been achieved in both basic and clinical research pertaining to thyroid cancer,leading to substantial updates in clinical diagnostic and therapeutic protocols and guidelines for various thyroid cancer subtypes.The advent and widespread application of next-generation sequencing technology in clinical practice have brought protein kinase fusion-driven thyroid cancer into sharper focus.This particular subtype accounts for over 10％of papillary thyroid carcinomas and frequently exhibits more aggressive histological characteristics and biological behaviors.The identification of kinase fusion-related thyroid cancer and the implementation of optimal detection strate-gies pose notable challenges for pathologists in China.This article provides a comprehensive review of the molecular mechanisms underlying phosphorylation signal transduction driven by kinase fusion,the pathological characteristics and detection methodologies of kinase fusion-related thyroid cancer,as well as the progress in research on related targeted therapies.The aim is to enhance the understanding of kinase fusion-related thyroid cancer,with the aspiration of facili-tating personalized and optimal diagnostic and therapeutic strategies in daily clinical practice,ultimately maximizing pa-tient outcomes.
