Influence of Hyperbaric Oxygen Combined with Huperzine A Treatment on Cognitive Function and Neuroinflammation in Patients with Vascular Cognitive Impairment after Cerebral Infarction
10.13241/j.cnki.pmb.2025.14.013
- VernacularTitle:高压氧联合石杉碱甲治疗对脑梗死后血管性认知障碍患者认知功能及神经炎症的影响
- Author:
Liu-fang SU
1
;
Guang-yan XU
1
;
Xin-jing LIN
1
Author Information
1. 广西壮族自治区民族医院神经内科 广西南宁 530001
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Huperzine A;
Cerebral infarction;
Vascular cognitive impairment;
Cognitive function;
Neuroinflammation
- From:
Progress in Modern Biomedicine
2025;25(14):2343-2350
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of hyperbaric oxygen combined with huperzine A treatment on cognitive function and neuroinflammation in patients with vascular cognitive impairment(VCI)after cerebral infarction.Methods:This study was a retrospective study.34 patients with VCI after cerebral infarction who were treated with hyperbaric oxygen combined with huperzine A in our hospital from January 2023 to October 2024 were selected as the observation group.Additionally using 1∶1 matched case-control study method,34 patients who were treated with hyperbaric oxygen alone during the same period were selected as the control group 1,and 34 patients who were treated with huperzine A alone were selected as the control group 2.Compared the clinical efficacy,cognitive function[mini mental state examination(MMSE)score,montreal cognitive assessment(MoCA)score],activities of daily living(Barthel index),neurological function[national institutes of health stroke scale(NIHSS),neuron specific enolase(NSE),brain-derived neurotrophic factor(BDNF)],inflammatory mediators[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1 β)]and incidence of adverse reactions among three groups.Results:The total clinical effective rate of the observation group was higher than that of control group 1 and control group 2(P＜0.05).After the treatment,the MMSE score,MoCA score and Barthel index of the observation group were higher than those of control group 1 and control group 2(P＜0.05).After the treatment,the NIHSS and NSE in the observation group were lower than those in control group 1 and control group 2,and the BDNF was higher than that in control group 1 and control group 2(P＜0.05).After the treatment,the levels of hs-CRP,IL-1β and TNF-α in the observation group were lower than those in control group 1 and control group 2(P＜0.05).There was no difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion:Hyperbaric oxygen combined with huperzine A in the treatment of VCI after cerebral infarction can increase the total clinical effective rate,improve patients' cognitive function and reduce levels of neuroinflammation.
