Research progress on the neuroinflammation mechanisms in bipolar disorder

VernacularTitle:双相障碍神经炎症机制的研究进展
Author: Xiaohong WANG ¹ ; Yiru FANG
Author Information

1. 上海交通大学医学院附属精神卫生中心精神科,上海 200030
Publication Type:Journal Article
Keywords: bipolar disorder; neuroglial cell; neuroinflammation; biomarker
From: Journal of Shanghai Jiaotong University(Medical Science) 2025;45(1):107-112
CountryChina
Language:Chinese
Abstract: Bipolar disorder(BD)is a chronic,recurrent mental illness characterized by extreme fluctuations in mood and state,clinically manifested as recurrent or alternating manic,depressive,and mixed episodes.The pathogenesis is complex and remains unknown,with neuroinflammation considered as a key factor in its development.In-depth research not only helps to understand the etiology,but also provides direction for the development of new therapeutic targets.This paper reviews recent studies on neuroinflammation in BD,discusses changes in peripheral and central inflammation and associated biomarkers,explores the underlying mechanisms of pathogenesis,and briefly describes the mechanisms and potential of mood stabilizers and new therapeutic drugs in anti-inflammatory effect,aiming to suggest possible future research directions.