Successful pregnancy and delivery of one patient with cytochrom P450 oxidoreductase deficiency after in vitro fertilization and embryo transfer: a case report and literature review
10.3760/cma.j.cn101441-20220617-00264
- VernacularTitle:细胞色素P450 氧化还原酶缺陷症患者经体外受精-胚胎移植成功妊娠分娩1例报道及文献复习
- Author:
Nana LIU
1
;
Xiumei ZHEN
;
Rong LI
;
Haining WANG
Author Information
1. 北京大学第三医院生殖医学中心，北京100191
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Adrenal hyperplasia, congenital;
Cytochrome P450 oxidoreductase
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):949-952
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the timely detection, differential diagnosis and effective treatment of cytochrome P450 oxidoreductase deficiency (PORD) with infertility.Methods:A retrospective analysis was conducted on the clinical diagnosis and treatment data of one PORD patient.Results:The disease characteristics of this patient included primary amenorrhea, infertility, mild malformation of the reproductive system, multiple luteinized cysts in the bilateral ovaries, and hyperprogesteronemia. PORD was diagnosed by endocrine testing indicators and gene screening. Oral dexamethasone was given, and in vitro fertilization and embryo transfer (IVF-ET) was carried out. After successful pregnancy, a healthy infant was successfully delivered. Conclusion:PORD is a rare autosome recessive genetic disease, which has steroid hormone metabolism disorder and various disease characteristics. It is easy to be misdiagnosed when combined with infertility. It needs timely differential diagnosis. After appropriate dexamethasone treatment, pregnancy can be successfully achieved through assisted reproductive technology.
