Advances in the study of the neuroendocrine marker INSM1
10.13315/j.cnki.cjcep.2025.01.014
- VernacularTitle:神经内分泌标志物INSM1的研究进展
- Author:
Xinyuan PAN
1
;
Zhiqiang LANG
Author Information
1. 山东省第二医科大学临床医学院,潍坊 261053;山东省烟台毓璜顶医院病理科,烟台 264001
- Publication Type:Journal Article
- Keywords:
neuroendocrine neoplasm;
INSM1;
immunohistochemistry;
neuroendocrine markers;
literature review
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(1):86-92
- CountryChina
- Language:Chinese
-
Abstract:
Insulinoma-associated protein 1(INSM1)is an emerging neuroendocrine marker that has received ex-tensive attention in previous studies.INSM1 demonstrates high sensitivity and specificity in neuroendocrine neoplasms(NENs)across various sites and grades.However,some studies have pointed out some inconsistencies in its expres-sion.This article explores the specific expression patterns of INSM1 in NENs of different systems,as well as in other tumors that express neuroendocrine markers.It also analyzes the critical role of INSM1 in the diagnosis of neuroendo-crine tumors and reviews its application value,prospects,and problems.
