Effect of PGT biopsy on perinatal outcome and offspring health
10.3760/cma.j.cn101441-20221128-00530
- VernacularTitle:PGT活检技术对妊娠围产结局及子代健康影响的分析研究
- Author:
Wenjuan PANG
1
;
Xu FENG
1
;
Xiang WANG
1
;
Liang WANG
1
;
Xiaoyuan HU
1
;
Ningxia SUN
1
Author Information
1. 海军军医大学第二附属医院生殖医学中心，上海 200003
- Publication Type:Journal Article
- Keywords:
Preimplantation genetic testing;
Sperm injection, intracytoplasmic;
Preterm birth;
Low birth weight;
Birth defect
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):550-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of preimplantation genetic testing (PGT) on perinatal outcome and offspring health.Methods:Retrospective case-control analysis was made on the data of patients undergoing PGT and intracytoplasmic sperm injection (ICSI) assisted pregnancy and single blastocyst transplantation in Reproductive Medicine Center of the Second Affiliated Hospital of Naval Medical University from January 2015 to August 2021. A total of 882 patients were included and 1 081 cycles of frozen-thawed embryo transfer (FET) were performed. Among them, 399 patients in the PGT group underwent 527 cycles, and 483 patients in the ICSI group underwent 554 cycles. According to the different indications of PGT technology, they were divided into PGT for structural rearrangements/monogenic defects/single gene defects monogenic (PGT-SR/M) subgroup and PGT for aneuploidies (PGT-A) subgroup. The clinical pregnancy rate, the abortion rate and the live birth rate were compared with those in the ICSI group. The clinical pregnancy after transplantation was analyzed, and the live birth was taken as the observation end point. There were 102 cases in the PGT-SR/M subgroup, 184 cases in the PGT-A subgroup, and 268 cases in the ICSI group. The perinatal outcome and the safety of offspring were compared respectively.Results:The clinical pregnancy rate in the PGT-SR/M subgroup [71.96% (136/189)] was higher than that in the ICSI group [61.73% (342/554), P=0.011], while there was no statistically significant difference between the PGT-A subgroup [64.50% (218/338)] and the ICSI group ( P>0.05). The live birth rate of both PGT-SR/M subgroup and PGT-A subgroup was higher than that of the ICSI group, but the differences were not statistically significant (all P>0.05). There were no statistically significant differences in the rates of miscarriage, premature birth, and pregnancy complications among the groups (all P>0.05). In addition, there were no statistically significant differences between the PGT-SR/M subgroup and the PGT-A subgroup in terms of low birth weight rate, macrosomia birth rate, and the incidence of birth defect (all P>0.05). The growth and development curve of children in the PGT group was normal within 2 years of age, and there were no statistically significant differences in height and weight between the PGT group and the ICSI group (all P>0.05). Conclusion:Under the same fertilization method, invasive embryo biopsy procedures did not increase the incidence of perinatal complications during pregnancy, and no adverse effects of PGT on the growth and development of offspring have been found.
