Research progress on the effect of advanced maternal age on maternal psychology and neurobehavioral development of their offspring and related mechanisms
10.3760/cma.j.cn101441-20221111-00502
- VernacularTitle:高龄妊娠对孕产妇心理及子代神经行为发育的影响及相关机制研究进展
- Author:
Fang LIU
1
;
Mengshi LI
;
Tian TIAN
;
Yu FU
;
Xiaoli WANG
;
Yuanyuan WANG
;
Jie QIAO
Author Information
1. 北京大学第三医院妇产科生殖医学中心 国家妇产疾病临床医学研究中心(北京大学第三医院) 辅助生殖教育部重点实验室（北京大学）北京市生殖内分泌与辅助生殖技术重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Maternal age;
Maternal health;
Developmental disabilities;
Neurobehavioral manifestations;
Glial cell line-derived neurotrophic factor;
Serotonin;
Oxytocin
- From:
Chinese Journal of Reproduction and Contraception
2024;44(1):77-82
- CountryChina
- Language:Chinese
-
Abstract:
With the changes in lifestyle, marriages and childbearing concepts, and population policies in recent years, the proportion of women with advanced maternal age (AMA) in China is rising rapidly. AMA and maternal stress due to advanced age are considered as independent risk factors for maternal mental health and the neurobehavioral development of their offspring. In this paper, we summarized how the glial cell line-derived neurotrophic factor, the hypothalamic-pituitary-adrenal axis, the 5-HT system and the oxytocin affect the maternal mental health and the neurobehavioral development of their offspring, as well as some potential targeted interventions. Interventions currently being developed include artificial supplements, antidepressants, physical exercise, nutrient supplementation, etc., but they have a limited efficacy and a high risk of side effects, yet there is still a lack of specific and systematic interventions. The relevant pathogenesis should continue to be explored in the future research, and hopefully more effective and safe interventions will be given in the near future to improve the mental health of mothers with AMA and the long-term healthy development of their offspring.
