Research progress of membrane-controlled reservoir sustained-release drug delivery systems for reproductive health
10.3760/cma.j.cn101441-20220116-00026
- VernacularTitle:膜控储库型缓释给药系统在生殖健康领域的研究进展
- Author:
Pan CHEN
1
;
Shasha WANG
;
Chuncao ZHAO
;
Yilin GUO
;
Zhepeng LIU
;
Linglin FENG
Author Information
1. 上海理工大学生命科学与工程学院，上海 200093
- Publication Type:Journal Article
- Keywords:
Contraception;
Sustained-release drug delivery systems;
Membrane-controlled reservoir;
Polymers;
Drug release model
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):650-657
- CountryChina
- Language:Chinese
-
Abstract:
Nowadays, the aging of China's population is becoming increasingly serious, and fertility of women under the national three-child policy is declining, both middle-aged and elderly women and women of childbearing age are facing reproductive health problems. Traditional oral preparations have a short acting time and some varieties have low bioavailability problems, while the long-acting sustained-release preparations have the advantages of convenient use, stable blood drug concentration and higher safety. Their development provides theoretical basis and technical support for the development and application of reproductive contraceptives. In the decades of research, a variety of different drug delivery systems have been born. Among them, the polymer-based membrane-controlled reservoir preparations, as a common drug sustained-release system, is mostly used in reproductive health and has broad market prospects. In this paper, polymer-based membrane-controlled reservoir drug delivery systems in the field of reproductive health was briefly reviewed, and four key issues including polymer material selection, in vitro drug release model, preparation types and research progress, and challenges were discussed, which can provide reference for the development of related contraceptives in the future.
