Research progress on the application of melatonin in oocyte cryopreservation
10.3760/cma.j.cn101441-20230106-00015
- VernacularTitle:褪黑素在卵母细胞冷冻保存中的应用研究进展
- Author:
Yongqi FAN
1
;
Dandan YANG
1
;
Yunxia CAO
1
;
Zhiguo ZHANG
1
Author Information
1. 安徽医科大学第一附属医院妇产科生殖中心，合肥 230032
- Publication Type:Journal Article
- Keywords:
Melatonin;
Oocyte;
Cryopreservation
- From:
Chinese Journal of Reproduction and Contraception
2023;43(2):164-168
- CountryChina
- Language:Chinese
-
Abstract:
During cryopreservation of oocytes, the high toxicity and high permeability of cryoprotectants often result in the imbalance of oxidant-antioxidant system in oocytes especially the increase of intracellular reactive oxygen species (ROS) content. As an effective antioxidant and free radical scavenger, melatonin can significantly reduce the level of ROS in oocytes by affecting energy metabolism and signal transduction, and protect mitochondrial function. At the same time, it also plays the role of scavenging free radicals in oocytes, and realizes the suppression of intracellular oxidative stress levels during freezing-thawing process, thereby reducing the cryoinjury of oocytes during cryopreservation, ultimately, improving the blastocyst formation rate of frozen-thawed oocytes and the clinical pregnancy rate after embryo transfer. The application of melatonin in oocyte cryopreservation has a positive significance for the research of female fertility preservation. This article reviews the progress of melatonin in oocyte freezing.
