Research progress on the risk of neurological and psychiatric disorders in offspring born from assisted reproductive technology
10.3760/cma.j.cn101441-20221204-00541
- VernacularTitle:辅助生殖技术对后代神经精神健康影响的研究进展
- Author:
Renyu MENG
1
;
Yanting WU
;
Hefeng HUANG
Author Information
1. 复旦大学附属妇产科医院妇科内分泌与生殖医学科，上海 200011
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Neurodevelopmental disorders;
Neurocognitive disorders
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):594-598
- CountryChina
- Language:Chinese
-
Abstract:
Assisted reproductive technology (ART) has made a great contribution to treat infertility and support population development. However, more and more studies have found that ART may bring various short-term and long-term health risks to the offspring due to its non-physiological in vitro operation, unnatural reproductive characteristics, and application in the critical period of gametes and embryonic development. Studies have found that the key operations of ART may affect the neurological and psychiatric health of offspring, including disease risk and academic performance, through affecting the gamete, the epigenetic regulatory program of the embryo, and the hormonal environment. This article reviewed the effects of ART on neurodevelopmental disorders, neurological diseases, and mental diseases in offspring, providing new ideas for the prevention and treatment of mental and neurological diseases and improving the safety of assisted reproduction.
