Research progress of ferroptosis and female reproductive-related diseases
10.3760/cma.j.cn101441-20221026-00469
- VernacularTitle:铁死亡与女性生殖相关疾病的研究进展
- Author:
Faminzi LI
1
;
Lianzhi WU
;
Jing YANG
Author Information
1. 武汉大学人民医院生殖医学中心 湖北省辅助生殖与胚胎发育医学临床研究中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
Iron metabolism;
Lipid peroxides;
Reproductive system
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1285-1290
- CountryChina
- Language:Chinese
-
Abstract:
Iron and iron metabolism are involved in regulating the physiological functions of the female reproductive system. Essential iron plays a positive role in female development and reproductive function, while iron overload can induce abnormal metabolic processes in the body. Ferroptosis is a cellular iron-dependent disorder of lipid oxide metabolism, accompanied by oxidative imbalance and accumulation of lipid reactive oxygen species. Studies have shown that ferroptosis occurred in the pathology of endometriosis, polycystic ovary syndrome and trophoblast dysfunction diseases. Besides, the pathways and related genes of ferroptosis are involved in early embryonic development, placental oxidative stress, and regulation of oocyte function, suggesting the possibility of key molecules of iron metabolism and ferroptosis as potential therapeutic targets. The regulation mechanism for ferroptosis in female reproduction-related diseases is unclear now.This review discussed and summarized the recent research progress of iron overload and ferroptosis in female reproductive system and related diseases, in order to provide reference for clinical treatment of related diseases.
