Clinicopathological and molecular genetic features in 8 cases of Warthin-like mu-coepidermoid carcinoma
10.13315/j.cnki.cjcep.2025.08.010
- VernacularTitle:Warthin瘤样黏液表皮样癌8例临床病理学及分子遗传学特征
- Author:
Yanping ZHANG
1
;
Enjie LIU
1
;
Ye LI
1
;
Xinquan LYU
1
;
Shenglei LI
1
;
Wencai LI
1
Author Information
1. 郑州大学第一附属医院病理科,郑州 450000
- Publication Type:Journal Article
- Keywords:
Warthin-like mucoepidermoid carcinoma;
Warthin tumor;
MAML2
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(8):1039-1044
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological and molecular genetic characteristics of Warthin-like mucoepidermoid carcinoma(WLMEC).Methods Eight cases of WLMEC were collected.HE staining,immunohisto-chemistry,and fluorescence in situ hybridization were performed to observe their histological morphology,immunophe-notype,and molecular genetic characteristics.Clinical information was analyzed,and follow-up was conducted.Re-sults Among the eight cases of WLMEC,three were male and five were female,aged from 28 to 65 years(median age:47 years),all occurring in the parotid gland.All eight cases had clear boundaries and appeared as polycystic structures.Besides the homogeneously eosinophilic material,blue-stained mucoid material was visible in the cyst cavi-ty.The epithelium was arranged in various ways,including single-layer,double-layer,or multi-layer.The cells had a bland-looking morphology with round or oval nuclei.Compared to Warthin tumor,the cytoplasm was significantly less eosinophilic and flatter.Mitotic figures were rare.A prominent lymphoid stroma with abundant plasma cell infiltration was observed,especially in areas adjacent to the epithelium.The tumor cells expressed CK(AE1/AE3),CK5/6,p63,and CK7.The epithelial arrangement was disordered,unlike the typical double-layered structure seen in Warthin tumor.The Ki67 index ranged from 1％to 5％.MAML2 gene rearrangement was detected in all eight cases.No recur-rence was observed during the follow-up period of 1 to 54 months after surgical resection.Conclusion WLMEC is a rare low-grade malignant tumor originating from salivary glands.Compared with Warthin tumor,patients with WLMEC are younger and more commonly female.The presence of epithelial cells that are not typically arranged in a regular double layer with strong eosinophilia,as well as the abundance of plasma cells beneath the epithelium,serve as impor-tant diagnostic clues.Performing MAML2 gene testing on suspicious cases can aid in the accurate diagnosis of this dis-ease.
