Clinicopathological analysis of 12 cases of CD23-positive diffuse large B-cell lym-phoma
10.13315/j.cnki.cjcep.2025.08.006
- VernacularTitle:表达CD23的弥漫性大B细胞淋巴瘤12例临床病理观察
- Author:
Susu ZHAO
1
;
Fei KE
;
Hui YU
;
Xiaoli CHEN
;
Yaohui WANG
;
Shuangshuang WANG
;
Yifen ZHANG
Author Information
1. 南京中医药大学附属医院/江苏省中医院 病理科,南京 210029
- Publication Type:Journal Article
- Keywords:
diffuse large B cell lymphoma;
CD23;
FCER2;
immune microenvironment
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(8):1011-1016
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features and possible tumor-associated immune micro-environment in CD23-positive diffuse large B-cell lymphoma(DLBCL).Methods The clinicopathological data of 12 cases of CD23-positive DLBCL patients were analyzed retrospectively.The clinical and pathological features were ana-lyzed,and the clinical correlation and tumor-associated immune invasion were studied.Results CD23-positive DL-BCL accounted for 9.45％of all DLBCL.There were 6 males and 6 females.The mean age of onset was 64.83 years old.Four DLBCL cases occurred in lymph nodes and 8 cases occurred outside lymph nodes.Nine DLBCL cases were in advanced stage(Ⅲ-Ⅳ)and 3 cases DLBCL were in early stage(Ⅰ-Ⅱ).Among the patients,3 cases were untreated and lost to follow-up.One case deteriorated and died after operation.Two cases died,1 case progressed and 5 cases partially recovered after chemotherapy.Microscopically,the tumor cells were diffusely infiltrated and destroyed the nor-mal tissue structure.The tumor cells were observed to be centroblastic,immunoblastic and anaplastic large cells.No blastoid transformation and plasmacytoid differentiation were observed in morphology.According to Hans algorithm,11 cases were non-GCB phenotype except 1 case was GCB phenotype.Bioinformatics studies revealed that CD23 expres-sion was correlated with regulatory T cells,NK cells,plasma-like dendritic cells and neutrophils.Conclusion CD23-positive DLBCL patients are mainly middle-aged and elderly,and most of them occur outside lymph nodes and in ad-vanced stage(Ⅲ-Ⅳ).Follow-up results show that their prognosis is poor.Morphologically,there is no significant difference between DLBCL and conventional DLBCL.The Hans classification suggests that most cases originated from activated B cells.CD23 expression may play a role in the immune microenvironment of DLBCL.
