Effect of low-dose atosiban on pregnancy outcome in patients with elective single embryo transfer
10.3760/cma.j.cn101441-20220823-00353
- VernacularTitle:小剂量阿托西班对选择性单胚胎移植患者妊娠结局的影响
- Author:
Xuanlin ZHANG
1
;
Yuanyuan WANG
1
;
Yixin ZHANG
1
;
Fengqin XU
1
Author Information
1. 天津市第一中心医院生殖医学科，天津 300192
- Publication Type:Journal Article
- Keywords:
Single embryo transfer;
Pregnancy outcome;
Live birth;
Atosiban;
Abortion
- From:
Chinese Journal of Reproduction and Contraception
2023;43(10):1041-1045
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of low-dose oxytocin receptor antagonist atosiban on the pregnancy outcome of the elective single embryo transfer (eSET).Methods:A retrospective cohort study was performed on the clinical data of patients who got eSET at Department of Reproductive Medicine, Tianjin First Central Hospital from January 2015 to August 2021 and had a first- or second-time embryo transfer. They were divided into fresh cleavage stage embryo cycles, frozen-thawed cleavage stage embryo cycles, and frozen-thawed blastocyst cycles, depending on the days of embryological development and the treatment strategy. Patients were divided into atosiban group and control group according to whether or not they received an intravenous injection of 6.75 mg of atosiban 30 min before implantation. Propensity score matching (PSM) with a ratio of 1∶2 was utilized to match the patients in each group. The differences in the rates of biochemical pregnancy, clinical pregnancy, abortion, ectopic pregnancy, live birth, and birth defects were evaluated.Results:PSM included 243 patients in fresh cleavage stage embryo cycles (81 patients in the atosiban group and 162 patients in control group), 210 patients in frozen-thawed cleavage stage embryo cycles (70 patients in the atosiban group and 140 patients in control group), and 216 patients in frozen-thawed blastocyst cycles (72 patients in the atosiban group and 144 patients in control group). At eSET of fresh cleavage stage embryos, frozen-thawed cleavage stage embryos, or frozen-thawed blastocysts, the biochemical pregnancy rate, the clinical pregnancy rate, the miscarriage rate, the ectopic pregnancy rate, the live birth rate, and the birth defect rate in atosiban group were not statistically different from those in control group (all P>0.05). Conclusion:Intravenous injection of low dosage of atosiban before eSET failed to significantly improve the pregnancy outcome of infertile patients.
