Research progress on the role of autophagy in the pathogenesis of idiopathic pulmonary fibrosis
10.3969/j.issn.1671-7856.2024.12.017
- VernacularTitle:自噬在特发性肺纤维化发病机制中的研究进展
- Author:
Weifei DU
1
;
Xuemin XU
;
Xiaoming LIU
Author Information
1. 山东中医药大学,济南 250014
- Publication Type:Journal Article
- Keywords:
autophagy;
idiopathic pulmonary fibrosis;
fibroblasts;
myofibroblasts;
alveolar epithelial cells;
macrophages;
endothelial cells
- From:
Chinese Journal of Comparative Medicine
2024;34(12):143-150
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a crucial physiological process in cells and an important mechanism in the maintenance of cell homeostasis and regulation of cell survival.Idiopathic pulmonary fibrosis(IPF)is an interstitial lung disease of unknown etiology with a poor prognosis,characterized by alveolar epithelial cell damage and abnormal proliferation and activation of fibroblasts.IPF is accompanied by the excessive deposition of extracellular matrix(ECM),and its pathogenesis involves a complex interaction between cell types and signaling pathways.Defects in autophagy function have been shown to play a key role in the occurrence and development of IPF.This review aims to investigate the mechanism of autophagy in IPF and reveal its complexity and related signaling pathways.
