Research progress in the mechanism of microRNA regulation in diarrhea-predominant irritable bowel syndrome and traditional Chinese medicine interventions
10.3969/j.issn.1671-7856.2024.12.015
- VernacularTitle:MicroRNA介导IBS-D的机制及中医药干预研究进展
- Author:
Changhui HE
1
;
Haidi PAN
;
Xin DOU
;
Xiao MEI
;
Hualiang DENG
;
Wei WANG
Author Information
1. 山东中医药大学第一临床医学院,济南 250014
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant irritable bowel syndrome(IBS-D);
miRNA;
mechanism of action;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Comparative Medicine
2024;34(12):127-135
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of diarrhea-predominant irritable bowel syndrome(IBS-D)remains high,with microRNA(miRNA)-mediated intestinal barrier dysfunction,visceral hypersensitivity,low-grade inflammation,and dysbiosis playing significant roles in its pathogenesis.Traditional Chinese medicines can treat IBS-D by directly or indirectly targeting miRNAs to regulate multiple pathways and targets in a coordinated manner.This article systematically reviews the involvement of miRNAs in the pathogenesis of IBS-D and the progress of traditional Chinese medicine interventions.It explores the relationship between traditional genetics,epigenetics,and the Chinese medicine concepts of'kidney'and'spleen'in terms of congenital and acquired interactions from a molecular biology perspective.This review thus provides a reference for exploring the micro-material basis of the'Zang-Xiang'theory of traditional Chinese medicine,and offers new ideas and method for the effective treatment of IaBS-D using traditional Chinese medicine.
