Research advances in regulation of the hypothalamic-pituitary-adrenal/hypothalamic-pituitary-thyroid/hypothalamic-pituitary-gonadal axes in the treatment of depression by traditional Chinese medicine
10.3969/j.issn.1671-7856.2024.12.012
- VernacularTitle:中医药调节HPA-HPT-HPG轴治疗抑郁症的研究进展
- Author:
Chao LI
1
;
Jian LI
;
Zhaoyang TIAN
;
Jingjing PU
;
Jiayu LI
;
Rujie HAN
;
Biwei ZHANG
;
Meng WANG
Author Information
1. 华北理工大学中医学院,河北唐山 063210
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
HPA;
HPT;
HPG;
depression;
research progress
- From:
Chinese Journal of Comparative Medicine
2024;34(12):102-110
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of depression is complex and treatment method are currently limited,and it is therefore important to clarify its pathogenesis and develop new therapeutic drugs.Hormones and hormone-modifying compounds have been used to treat depression,and their therapeutic effects are attributed to regulation of the peripheral endocrine system and their effects on non-endocrine circuits in the central nervous system.The hypothalamic-pituitary-adrenal(HPA)/hypothalamic-pituitary-thyroid(HPT)/hypothalamic-pituitary-gonadal(HPG)axes are closely related to the pathogenesis of depression.The mechanism of action of traditional Chinese medicines in the treatment of depression is extensive,and the three axes are regulated in a variety of ways.Based on new evidence of hormones and hormone operon compounds involved in the pathology and treatment of depression,this review summarizes the relevant mechanisms of current traditional Chinese medicine in the treatment of depression,to provide new ideas and references for traditional Chinese medicine research.
