Clinical practice of fertility preservation in young unmarried breast cancer patients
10.3760/cma.j.cn101441-20220626-00276
- VernacularTitle:年轻未婚乳腺癌患者生育力保存临床实践
- Author:
Mengxi GUO
1
;
Xiaojun CHEN
1
;
Dandan WU
1
;
Min WANG
1
;
Li WANG
1
;
Wen LI
1
Author Information
1. 上海交通大学医学院国际和平妇幼保健院生殖医学中心，上海 200030
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Fertility preservation;
Oocyte;
Vitrification;
Single person
- From:
Chinese Journal of Reproduction and Contraception
2023;43(2):129-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical practice of fertility preservation in unmarried young female breast cancer patients in China.Methods:This was a retrospective study of 13 unmarried female patients who underwent fertility preservation due to breast cancer in the Reproductive Medicine Center of International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine from January 2019 to December 2020.Results:The age of the patients was (31.00±3.98) years old. Nine patients used follicular phase letrozole (LE)+gonadotropin (Gn) ovarian stimulation protocol, 3 patients used luteal phase LE+Gn stimulation protocol, and 1 patient used natural cycle protocol. Eleven patients completed the fertility preservation procedure, with a total Gn used dosage of (1 865.91±501.03) U, estradiol level at trigger of (1 223.85±709.75) ng/L, and 9.91±4.41 frozen oocytes. All of them used vitrification freezing.Conclusion:Oocyte vitrification frozen after LE+Gn ovarian stimulation is the preferred solution in young unmarried breast cancer patients for fertility preservation. However, promoting the awareness of fertility preservation, improving communication between clinical departments, and increasing clinical practice still need to be promoted.
