Research progress in animal models of insomnia based on combination of disease and syndrome
10.3969/j.issn.1671-7856.2024.12.010
- VernacularTitle:病证结合失眠动物模型的研究进展
- Author:
Zhongmin ZHAO
1
;
Shuzhi LIANG
;
Xiangye GAO
;
Suyu HOU
;
Dandan LUO
;
Yan ZHANG
;
Shijun WANG
Author Information
1. 山东中医药大学中医学院,济南 250355
- Publication Type:Journal Article
- Keywords:
insomnia;
animal model;
combination of disease and syndrome;
TCM syndrome
- From:
Chinese Journal of Comparative Medicine
2024;34(12):85-95
- CountryChina
- Language:Chinese
-
Abstract:
Insomnia is a prevalent clinical condition that not only diminishes the patient's quality of life but also has the potential to give rise to further health complications.Traditional Chinese medicine(TCM)has been used to treat insomnia for thousands of years,with distinct advantages.TCM uses syndrome differentiation and therapy to achieve its therapeutic effects,by regulating the internal balance of the human body.To gain a deeper understanding of how TCM treats insomnia,it is crucial to create animal models that exhibit insomnia symptoms closely resembling those found in humans.This review summarizes the current disease-syndrome combination models,which can be classified into four categories:liver depression and Qi stagnation,heart-spleen deficiency,heart-kidney incompatibility,and Yin and blood deficiency.This paper focuses on specific modelling method ologies,assessment indicators,and model performances,with the aim of enhancing our understanding of the pathophysiology of insomnia in the context of TCM,and providing technical assistance for clinical efficacy evaluation and the creation of novel drugs.
