Anti-inflammatory effect and mechanism of alcohol extract of Polyrhachis dives against rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.08.012
- VernacularTitle:拟黑多刺蚁醇提物抗类风湿关节炎炎症反应及机制研究
- Author:
Lidan HE
1
;
Kaijun ZHAO
;
Lulu LIU
;
Ziqian HUANG
;
Yuhan WANG
;
Haili WANG
Author Information
1. 南京中山制药有限公司,江苏省中药经典名方工程技术研究中心,南京 210046;中国药科大学中药学院,南京 211198
- Publication Type:Journal Article
- Keywords:
Polyrhachis dives;
Rheumatoid arthritis;
Macrophage;
Anti-inflammatory;
Immunomodulation
- From:
Chinese Journal of Immunology
2025;41(8):1865-1872
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the anti-inflammatory activity of alcohol extract of Polyrhachis dives(PDAEs)against rheumatoid arthritis(RA)in vitro and in vivo.Methods:In vivo and in vitro anti-RA inflammatory response of PDAEs was investigated using a rat model of collagenous arthritis induced by bovine type Ⅱ collagen and an LPS-induced RAW264.7 cell inflammatory model.Results:PDAEs inhibited the polarization of M1 type macrophages in vivo and in vitro,reduced expressions of TNF-α,IL-1β,IL-6,iNOS,and promoted polarization of M2 type macrophages,enhanced expressions of anti-inflammatory cytokines,such as IL-10 and TGF-β,so as to achieve the anti-inflammatory effect.The experiments in vivo also showed that PDAEs had the immunomodulatory effect,the potential mechanism may be the regulation of Th17/Treg balance by regulating the expression of PD-1 and TGF-β,thus correcting the over-strong autoimmune response.Conclusion:PDAEs may reduce the inflammatory reaction of RA through anti-inflam-matory and immunomodulatory effects.
