Research progress on the preparation of animal models of non-alcoholic fatty liver disease and combination of disease and syndrome
10.3969/j.issn.1005-4847.2024.12.013
- VernacularTitle:非酒精性脂肪性肝病动物模型制备及病证结合研究进展
- Author:
Chunxia MA
1
;
Zhendong CHEN
;
Xudong TIAN
Author Information
1. 甘肃中医药大学,兰州 730000
- Publication Type:Journal Article
- Keywords:
non-alcoholic fatty liver disease;
animal model;
disease-syndrome combination model;
evaluation of model
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(12):1616-1625
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease(NAFLD)is a metabolic syndrome caused by a variety of pathogenic factors and characterized by the excessive deposition of fat in liver cells.At present,the pathogenesis of NAFLD is not fully understood,and there is a lack of specific drugs for NAFLD in clinical practice.Therefore,the establishment of an ideal animal model is extremely important for clarifying the pathogenesis of NAFLD and developing specific drugs and treatments.In addition to NAFLD animal models,an increasing number of disease-syndrome combined models related to NAFLD has emerged with the continuous renewal and development of traditional Chinese medicine over the past five years.This article summarizes the NAFLD animal models commonly used within the past five years,as well as their preparation and evaluation method,to provide a reference for future studies in NAFLD animal model preparation and modeling a combination of disease and syndrome.
