Relationship between serum anti-Müllerian hormone and rate of euploid blastocysts in patients undergoing preimplantation genetic testing for aneuploidies (PGT-A)
10.3760/cma.j.cn101441-20221103-00482
- VernacularTitle:胚胎植入前非整倍体遗传学检测患者血清抗苗勒管激素水平与囊胚整倍体率的相关性研究
- Author:
Shan LI
1
;
Shuo HUANG
1
;
Kailun HU
1
;
Jin HUANG
1
;
Lixue CHEN
1
;
Rong LI
1
Author Information
1. 北京大学第三医院生殖医学中心，北京 100191
- Publication Type:Journal Article
- Keywords:
Propensity score;
Anti-Müllerian hormone;
Aneuploidy;
Preimplantation genetic testing for aneuploidies
- From:
Chinese Journal of Reproduction and Contraception
2023;43(5):483-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the impact of serum anti-Müllerian hormone (AMH) on the rate and number of euploid blastocysts among women undergoing intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidies (PGT-A).Methods:A retrospective cohort study was performed by analyzing clinical data from 504 patients approaching ICSI cycle with PGT-A in Reproductive Medicine Center of Peking University Third Hospital from January 1st 2018 to December 31st 2020. According to serum AMH level measured before ovarian stimulation, subjects were divided into two groups: the low AMH group (AMH<1.00 μg/L, 85 patients) and the normal AMH group (AMH≥1.00 μg/L, 419 patients). Rates and number of euploid blastocysts were compared between the two groups (82 patients per group) after using propensity score matching (PSM) to adjust confounding variables, including age, body mass index (BMI), history of recurrent miscarriage and ovarian stimulation protocols.Results:1) The rate and number of euploid blastocysts were significantly lower in the low AMH group [50.0% (0, 100.0%), 1 (0, 1)] than in the normal AMH group [60.0% (33.3%, 100.0%), P=0.025; 1 (1, 2), P<0.001]. 2) After PSM, the rate of euploid blastocysts was 50.0% (0, 100.0%) in the low AMH group and 50.0% (19.2%, 100.0%) in the normal AMH group, with no significant difference ( P=0.265). Patients in the low AMH group had significantly fewer euploid blastocysts [1 (0, 1) vs. 1 (1, 2), P=0.004] and were less likely to have at least one euploid blastocyst [57.3% (47/82) vs. 76.8% (63/82), P=0.008]. 3) A total of 378 (75.0%) cycles had at least one euploid embryo. The area under the curve (AUC) value of AMH combined with age in predicting the presence of at least one euploid embryo was better than that of age alone (0.78 vs. 0.75, P=0.024). Conclusion:Serum AMH level is not independently associated with the rate of blastocyst euploidy after adjusting for age, BMI, history of recurrent abortion and ovulation induction protocol. AMH combined with age can be used to predict the possibility of having at least one euploid embryo per cycle.
