Research progress on the relationship between female reproductive tract microbiota and ectopic pregnancy
10.3760/cma.j.cn101441-20221026-00472
- VernacularTitle:女性生殖道菌群与异位妊娠相关性的研究进展
- Author:
Yimeng GE
1
;
Shuo YANG
1
;
Rong LI
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心 国家妇产疾病临床医学研究中心（北京大学第三医院）辅助生殖教育部重点实验室（北京大学）北京市生殖内分泌与辅助生殖技术重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Pregnancy, ectopic;
Repoductive tract infections;
Fallopian tubes;
Microbiota;
Endometrium receptivity
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1278-1284
- CountryChina
- Language:Chinese
-
Abstract:
Ectopic pregnancy is one of the most common adverse pregnancy outcomes during first trimester, and is generally believed to be caused by disorders of the fallopian tube, the endometrium and the embryo, accompanying genetic, environmental, immune, pathogen infection and other endocrine abnormalities. With the development of the macro genome sequencing, the female genital tract flora was confirmed to be closely linked with the establishment of endometrium receptivity, the regulation of genital tract inflammation and maintaining immune environment stability. It also plays an essential role in ovulation, fertilization, embryo transport and implantation. Studies suggested that genital tract dysbiosis might cause adverse pregnancy outcomes such as infertility, miscarriage, preterm birth, and ectopic pregnancy, which severely endanger women's security and safety. It suggests that genital tract microbiota may be associated with impaired functions of the reproductive system that potentially lead to ectopic pregnancy. This article mainly summarizes the research progress of the correlation between female genital tract microbiota and ectopic pregnancy, discusses the normal composition of genital tract microbiota and the potential mechanism of ectopic pregnancy caused by microbiota dysbiosis, so as to provide reference for clinical intervention.
