Role of DNA methyltransferases in neuroprotection during hypoxia/ischemia preconditioning
10.3969/j.issn.1671-7856.2024.12.013
- VernacularTitle:DNA甲基转移酶在缺氧/缺血预处理DNA中的神经保护作用研究
- Author:
Ruixue LI
1
;
Yabin XIE
;
Guo SHAO
Author Information
1. 包头医学院低氧转化医学重点实验室,内蒙古包头 014040
- Publication Type:Journal Article
- Keywords:
nerve protection;
hypoxic/ischemic preconditioning;
DNA methyltransferases
- From:
Chinese Journal of Comparative Medicine
2024;34(12):111-116
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic/ischemic preconditioning(H/IPC)can induce endogenous protective mechanisms that increase the tolerance of nerve cells to hypoxia/ischemia.This protective mechanism involves changes in gene expression during the critical decision-making period between cell survival and death.DNA methylation,as a crucial mechanism for gene expression regulation,plays an essential role in hypoxia/ischemia tolerance.DNA methyltransferases(DNMTs)contribute to neuroprotection by influencing gene expression via regulating DNA methylation levels.DNMTs thus have important functions in the neuroprotection induced by hypoxic/ischemic preconditioning.This paper reviews the role of DNMTs in this process,providing insights into neuroprotection targeting DNMTs.
