Research progress on the mechanism of berberine in the prevention and treatment of Parkinson's disease
10.3969/j.issn.1671-7856.2024.12.011
- VernacularTitle:小檗碱防治帕金森病的作用机制研究进展
- Author:
Hongyu LI
1
;
Rui LAN
;
Chen TANG
;
Shuang LIU
;
Yong ZHANG
;
Xiaoming SHEN
Author Information
1. 河南中医药大学第一附属医院脑病中心,郑州 450000;河南中医药大学第一临床医学院,郑州 450000
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
berberine;
pathogenesis;
α-synuclein
- From:
Chinese Journal of Comparative Medicine
2024;34(12):96-101
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a neurodegenerative disease that primarily affects middle-aged and older adults.Its main clinical manifestations include resting tremor,bradykinesia,myotonia,and balance disorders.Berberine is a naturally occurring isoquinoline alkaloid.Several studies over the previous decade have reported that berberine plays a crucial role in the pathophysiologic processes of a range of diseases,including playing an active role in the development of PD via different pathways.This paper systematically reviews the mechanism of action of berberine in the prevention and treatment of PD and the current status of research,to provide references for the future clinical application of berberine for the treatment of PD.
