First testis cryopreservation of prepuberty boys in China: a report of 3 cases and literature review
10.3760/cma.j.cn101441-20221108-00490
- VernacularTitle:中国首次青春期前男孩睾丸组织冷冻保存3例报道并文献复习
- Author:
Guihua LIU
1
;
Menghui MA
;
Wenlong SU
;
Lubin YAN
;
Dejuan SUN
;
Jing ZHANG
;
Haitao LI
;
Yalu ZHENG
;
Huisi MAI
;
Lugang ZHAO
;
Peng SUN
;
Haitao ZENG
;
Cong FANG
;
Dejuan WANG
;
Xiaoyan LIANG
Author Information
1. 中山大学附属第六医院生殖中心，广州 510655
- Publication Type:Journal Article
- Keywords:
β-thalassemia;
Testicular tissue freezing;
Controlled slow freezing;
Male;
Fertility preservation
- From:
Chinese Journal of Reproduction and Contraception
2023;43(1):84-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the method of fertility preservation in severe β-thalassemia prepubertal boys who cannot produce sperm before gonadotoxicity therapy.Methods:Three cases of severe β-thalassemia patients who were going to undergo hematopoietic stem cell transplantation (HSCT) were reported. They were received testis cryopreservation by slow-rate freezing. The necessity of fertility preservation in prepubertal boys and the methods of fertility persevation, testicular cryopreservation and the downstream techniques were stated.Results:Totally 31, 31, 20 pieces of testicular tissue were frozen by slow-rate freezing in three boys respectively and the freezing process went smoothly.Conclusion:The cryopreservation of testicular tissue can preserve the fertility of severe β-thalassemia prepuberty boys who will receive HSCT, leaving hope for offspring.
