Research advances in endometrial organoids
10.3760/cma.j.cn101441-20211221-00567
- VernacularTitle:子宫内膜类器官研究进展
- Author:
Wenxin LI
1
;
Zhengli ZHOU
Author Information
1. 昆明理工大学灵长类转化医学研究院 省部共建非人灵长类生物医学国家重点实验室，昆明 650500
- Publication Type:Journal Article
- Keywords:
Organoids;
Endometriosis;
Endometrial hyperplasia;
Endometritis;
Polycystic ovary syndrome;
Endometrial;
Endometrial cancer
- From:
Chinese Journal of Reproduction and Contraception
2023;43(4):422-427
- CountryChina
- Language:Chinese
-
Abstract:
Endometrial organoids (EOs) are three-dimensional aggregates of endometrial cells, which represent the structure and function of endometrium. According to the number of cell types contained, EOs can be divided into two categories, single-cell EOs and multicellular EOs. EOs will accelerate our understanding of the molecular and cellular mechanisms of endometrial development and diseases, and will become a promising tool for biomedical applications from disease modeling to personalized medicine. This review described the phenotype (typical surface markers and structure), genetic characteristics, culture medium, response to hormones, simulated disease model, challenges and future prospects of EOS.
