Research advances of CXCL12/CXCR4 in the rheumatoid arthritis pathogenesis
- VernacularTitle:CXCL12/CXCR4在类风湿关节炎中的研究进展
- Author:
Hong-mei YANG
1
;
Hao-lin LI
;
Juan-juan YANG
;
Xiao-jun SU
;
Hai-tao LEI
;
Dong-sheng LU
;
Li-li KAN
;
Peng-fei TAO
;
Hai-dong WANG
Author Information
- Publication Type:Journal Article
- Keywords: CXCL12; CXCR4; chemokines; rheumatoid arthri-tis; antagonist; targeted therapy
- From: Chinese Pharmacological Bulletin 2025;41(2):230-234
- CountryChina
- Language:Chinese
- Abstract: Rheumatoid arthritis(RA)is a chronic autoimmune disease of unknown etiology that can cause joint destruction and deformity.As a small molecule cytokine,the chemokine C-X-C motif chemokine ligand 12(CXCL12)regulates the pathogenesis of rheumatoid arthritis by binding to the specific receptor CXC chemokine receptor 4(CXCR4).Therefore,based on the bio-logical characteristics of CXCL12 and CXCR4,this paper intro-duces the pathogenesis of CXCL12/CXCR4 in RA and summari-zes the progress in RA-related research,with the aim of providing clinical value for understanding the pathogenesis of RA and de-veloping novel therapeutic targets.
