Advances in biological functions of osteopontin in central nervous system
- VernacularTitle:中枢神经系统中骨桥蛋白生物学功能的研究进展
- Author:
Yi-wen WANG
1
;
Ya-jun SHI
;
Qian MENG
;
Na CUI
;
Yi DING
Author Information
- Publication Type:Journal Article
- Keywords: osteopontin; central nervous system; biological function; microglia; astrocytes; neurons
- From: Chinese Pharmacological Bulletin 2025;41(2):225-229
- CountryChina
- Language:Chinese
- Abstract: Osteopontin(OPN)is a multifunctional protein,widely distributed in a variety of cells,tissues,organs and body fluids.This protein has a classical RGD domain and can bind to a variety of integrins and CD44 receptors,thereby participating in various pathological processes in the body,such as infection,allergic reaction,autoimmune and tissue damage.Recently,many studies have revealed that OPN is highly expressed in the central nervous system(CNS)and plays different regulatory roles in CNS diseases,that is,OPN can play a pro-inflammatory role in some conditions to stimulate neurotoxicity,while it can play a neuroprotective role in other conditions.While there has been growing interest in the biological role of OPN in the CNS,a comprehensive review is currently lacking.The purpose of this paper is to provide an overview of the expression and function of OPN in the CNS,with a focus on microglia,astrocytes,and neurons.
