Modulation of ferroptosis by traditional Chinese medicine to alleviate bone destruction in rheumatoid arthritis:A review
10.3969/j.issn.1000-484X.2025.08.001
- VernacularTitle:中药调控铁死亡缓解类风湿关节炎骨破坏的研究进展
- Author:
Mei YANG
1
;
Xiaolan SHEN
;
Xiaoqiang HOU
;
Huilian HUANG
;
Zhitao FENG
Author Information
1. 三峡大学基础医学院,宜昌 443002;三峡大学国家中医药管理局中药药理(肿瘤)科研三级实验室,宜昌 443002
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Iron metabolism;
Ferroptosis;
Bone destruction;
Traditional Chinese medicine
- From:
Chinese Journal of Immunology
2025;41(8):1793-1799
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a chronic,systemic,autoimmune inflammatory disease.Bone destruction caused by RA is a key factor in disability,involving abnormal activation of immune cells,overproduction of inflammatory factors,and imbalances in bone remodeling process.Ferroptosis,a form of cell death associated with disturbed iron metabolism,inactivation of the antioxidant system and lipid peroxidation,plays a complex role in RA bone destruction.Traditional Chinese medicine(TCM),with its multi-targeted intervention properties,has shown significant potential and advantages in treatment of RA bone destruction.A variety of TCM can regulate the ferroptosis pathway and influence osteoblast function,which has an important role in slowing down RA bone destruction.This review focuses on the latest research progress in the regulation of ferroptosis pathway by TCM to alleviate RA bone destruction,aiming to provide new perspectives and theoretical basis for the treatment of RA bone destruction.
