Management of the uterine abnormalities on the reproductive outcomes in women with repeated implantation failure
10.3760/cma.j.cn101441-20221001-00429
- VernacularTitle:宫腔异常治疗对反复种植失败患者助孕结局的影响
- Author:
Likun WEI
1
;
Yanfang ZHANG
1
;
Wenyan TIAN
1
;
Yonghuan LYU
1
;
Jing ZHANG
1
;
Xueru SONG
1
;
Xiaohong BAI
1
Author Information
1. 天津医科大学总医院妇产科生殖医学中心 天津市女性生殖健康与优生重点实验室，天津 300052
- Publication Type:Journal Article
- Keywords:
Hysteroscopy;
Repeated implantation failure;
Reproductive outcome;
Uterine abnormalities;
Chronic endometritis
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):939-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the reproductive outcomes of the subsequent embryo transfer (ET) cycles in women with repeated implantation failure (RIF) after the management of uterine cavity abnormalities.Methods:This was a retrospective case-control study. The clinical data of 89 patients with repeated implantation failure who underwent hysteroscopy at Reproductive Medicine Center of the Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital from January 1, 2017 to March 31, 2021 were analyzed. The patients were assigned to a normal uterine cavity (UC) group ( n=38) and an abnormal UC group ( n=51) according to hysteroscopic examination and endometrial biopsy results. Women in the abnormal UC group received relevant treatments, and all patients received the embryo transfer again. The reproductive outcomes were compared between the two groups in the subsequent ET cycles. Results:The prevalence of uterine abnormalities was 57.30% (51/89) in women with RIF. Chronic endometritis accounted for the highest incidence 39.33% (35/89). Among 38 women in normal UC group, 16 women got clinical pregnancy in the subsequent ET cycles, and 24 women in 51 got clinical pregnancy in the abnormal UC group. There were no differences in the implantation rate, the clinical pregnancy rate, and the ectopic pregnancy rate between the two groups (all P>0.05). The early abortion rate was significantly higher in the normal UC group [37.50% (6/16)] than in the abnormal UC group [8.33% (2/24), P=0.042]. Conclusion:The uterine abnormalities mainly occurred in women with primary infertility. The clinical pregnancy rate of women after correction of uterine abnormalities was similar to those women with normal UC. Hysteroscopy was advised to performed routinely to evaluate the uterine environment in women with RIF.
