Application and research progress of single cell sequencing technology in reproductive medicine
10.3760/cma.j.cn101441-20220407-00147
- VernacularTitle:单细胞测序技术在生殖医学中的应用及研究进展
- Author:
Wenhan JU
1
;
Shuai ZHAO
;
Danqi LIU
;
Fang LIAN
Author Information
1. 山东中医药大学第一临床医学院，济南 250014
- Publication Type:Journal Article
- Keywords:
Reproductive medicine;
Oocytes;
Sperm;
Embryonic development;
Single cell sequencing technology
- From:
Chinese Journal of Reproduction and Contraception
2023;43(8):852-859
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, single cell sequencing technology has developed rapidly. With the advantages of few cells needed, high throughput and high sensitivity, it has been applied to genome sequencing and transcriptome sequencing of human tissues and cells to facilitate the research of cell interaction and cell heterogeneity. Under the influence of the complex factors such as the change of marriage and childbirth, social and environmental factors, the incidence rate of infertility has increased year by year. How to protect human fertility has become a social hot spot. The application of single cell sequencing technology in assisted reproduction reveals the development, maturation and aging laws of germ cells more accurately, explains the law of early embryonic development, decrypts the molecular regulation research mechanism of reproductive diseases from the genetic level and epigenetic modification. This article reviewed the application progress of single cell sequencing technology in the field of reproduction, in order to provide a reference for further exploring the development track, pathological changes, genetic diagnosis and molecular regulation mechanism of human reproductive system.
