Research progress of SNARE complex in autophagy and related diseases
10.3969/j.issn.1000-4718.2024.00.030
- VernacularTitle:SNARE复合物在自噬及相关疾病中的研究进展
- Author:
Caiyin LI
1
;
Yuan LIU
;
Roujia GUO
;
Jingjing BU
;
Xiangli YAN
;
Yucheng LI
Author Information
1. 河南中医药大学豫药全产业链研发河南省协同创新中心,河南中医药大学中医药科学院,河南省仲景方药现代研究重点实验室,河南 郑州 450046;河南中医药大学药学院,河南 郑州 450046
- Publication Type:Journal Article
- Keywords:
SNARE complex;
autophagy;
autophagosome;
lysosome
- From:
Chinese Journal of Pathophysiology
2025;41(1):188-194
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a conserved physiological phenomenon commonly found in all eukaryotic cells,which promotes cell survival by degrading intracellular proteins and organelles during starvation or nutrient deficiency.Dysfunc-tion autophagy is closely related to various diseases.Soluble N-elthylmaleimide-sensitive factor attachment protein recep-tor(SNARE)complex is a protein complex that mediates membrane fusion and plays a key role in the fusion process of au-tophagosomes and lysosomes.The aberrant assembly of the SNARE complex results in the arrest of autophagic flow,there-by leading to cellular dysfunction and the occurrence of diseases.In this review,we summarized the roles of SNARE pro-teins in the autophagosome-lysosome fusion and the latest research in related diseases,providing a reference for studying the mechanism of autophagy and diseases targeting the SNARE complex.
