Advances in endoplasmic reticulum stress-regulated cytokine secretion by immune cells
10.3969/j.issn.1000-4718.2025.01.018
- VernacularTitle:内质网应激对免疫细胞分泌细胞因子调节作用的研究进展
- Author:
Ning XU
1
;
Youqi ZHAO
1
;
Lingzhi XU
1
Author Information
1. 山东第二医科大学基础医学院,山东省高等学校免疫微环境与炎症性疾病研究特色实验室,山东 潍坊 261053
- Publication Type:Journal Article
- Keywords:
endoplasmic reticulum stress;
unfolded protein response;
cytokines;
immune cells
- From:
Chinese Journal of Pathophysiology
2025;41(1):157-164
- CountryChina
- Language:Chinese
-
Abstract:
Within the lumen of the endoplasmic reticulum,secretory proteins are synthesized,processed,and transported.Disturbances in Ca2+or internal environmental homeostasis trigger the production of misfolded or unfolded proteins,thereby inducing endoplasmic reticulum stress(ERS).The ERS maintains the correct folding of secretory pro-teins by activating three signaling pathways in the unfolded protein response:inositol-requiring enzyme 1(IRE1),protein kinase R-like endoplasmic reticulum kinase(PERK),and activating transcription factor 6(ATF6).In disease states such as viral infections,autoimmune diseases,and inflammation,activated immune cells secrete large amounts of cytokines,which are small molecule secretory proteins.The ERS regulates the balance of its secretory pathways,thereby affecting cellular function.The precise mechanism by which ERS affects immune cells regulating cytokine secretion remains to be fully revealed.This article provides a comprehensive review of the research progress on the role and mechanism of ERS in regulating the secretion of cytokines by immune cells.
