Serum miR-205,miR-23b,and miR-25 levels in patients with sepsis and their correlation with prognosis
10.12007/j.issn.0258-4646.2025.08.008
- VernacularTitle:脓毒症患者血清miR-205、miR-23b、miR-25水平及其与预后的相关性
- Author:
Min ZHANG
1
;
Wenyu ZHANG
1
;
Jingjing TIAN
1
;
Meiqi GUO
1
;
Hairong CHANG
1
Author Information
1. 衡水市人民医院重症医学科,河北 衡水 053000
- Publication Type:Journal Article
- Keywords:
sepsis;
miR-205;
miR-23b;
miR-25;
prognosis
- From:
Journal of China Medical University
2025;54(8):714-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes in serum miR-205,miR-23b and miR-25 levels and their correlation with the prognosis of patients with different severities of sepsis.Methods A retrospective study was conducted in 86 patients with sepsis admitted to our hospital between September 2021 and September 2023.Based on the severity of illness,patients were divided into mild(52 cases)and severe(34 cases)groups.Eighty healthy individuals undergoing medical check-ups during the same period were selected as controls.The patients were follo wed-up for 28 days and were then categorized into a survival group(68 patients)and a death group(18 patients).Real-time polymerase chain reaction was used to detect the serum miR-205,miR-23b,and miR-25 levels in patients and analyze their corre-lation with prognosis.Multivariate Cox regression analysis was used to analyze the risk factors affecting patient prognosis.The diagnostic value of serum miR-205,miR-23b,and miR-25 levels in assessing sepsis and their predictive value for prognosis were analyzed using receiver operating characteristic curves.Results Serum miR-205,miR-23b,and miR-25 levels were significantly lower in the two groups of patients with sepsis than in the control group(P＜0.05),and were significantly higher in the survival group than in the death group(P＜0.05).Their levels negatively correlated with prognosis.Heart rate and APACHE Ⅱ score were risk factors for a poor prognosis of patients with sepsis,whereas high serum miR-205,miR-23b,and miR-25 levels were protective factors(P＜0.05).The areas under the curve(AUC)for individual serum miR-205,miR-23b,and miR-25 levels and their combination to assess sepsis were 0.794,0.786,0.768,and 0.926,respectively.The AUC for predicting poor prognosis for patients were 0.776,0.762,0.797,and 0.918,respectively.Conclusion Serum miR-205,miR-23b,and miR-25 levels were reduced in patients with sepsis,and were closely correlated with patient prognosis.Thus,they may serve as serological biomarkers for assessing disease and predicting prognosis.
