Mechanism of action of the RNA-binding protein CELF1 in diseases
10.12007/j.issn.0258-4646.2025.08.001
- VernacularTitle:RNA结合蛋白CELF1在疾病中的作用机制
- Author:
Yan YAN
1
;
Yi ZHANG
1
Author Information
1. 中国医科大学附属第一医院妇科,沈阳 110001
- Publication Type:Journal Article
- Keywords:
CELF1;
RNA-binding protein;
disease;
cancer
- From:
Journal of China Medical University
2025;54(8):673-677
- CountryChina
- Language:Chinese
-
Abstract:
CELF1 is a multifunctional RNA-binding protein that plays important roles in growth and development by regulating gene expression.CELF1 is involved in mRNA splicing,stability,and regulation of translation,and affects cell proliferation,apoptosis,and cell-cycle processes.In recent years,CELF1 has been implicated in the progression of several non-neoplastic diseases,such as myotonic dystrophy type 1,cardiac hypertrophy,cataract,and type 2 diabetes.In addition,CELF1 is abnormally expressed in many cancers,such as colorectal cancer,hepatocellular carcinoma,non-small cell lung cancer,glioma,and breast cancer,and is closely associated with deve-lopment and drug resistance of these cancers.CELF1 is a potential target for treating diseases,but further studies are required.
