Clinicopathological features of 11 cases of intrathyroid thymic carcinoma
10.13315/j.cnki.cjcep.2025.01.011
- VernacularTitle:甲状腺内胸腺癌11例临床病理特征
- Author:
Lianying WANG
1
;
Yang LEI
;
Wen SHAO
;
Zhenzhong FENG
;
Xian WANG
;
Nan LI
Author Information
1. 蚌埠医科大学第一附属医院病理科,蚌埠 233004
- Publication Type:Journal Article
- Keywords:
thyroid neoplasm;
thymic carcinoma;
immunohistochemistry;
differential diagnosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(1):69-73,80
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological features,diagnosis,differential diagnosis,treatment,and prognosis of intrathyroid thymic carcinoma(ITC).Methods The clinical manifestations,histological features and immunophenotypes of 11 patients with ITC were retrospectively analyzed.Immunohistochemistry and Sanger sequencing were used for protein and gene detection.The relevant literature is retrieved and the data of this paper is analyzed sta-tistically.Results Among the 11 patients,6 were female and 5 was male,aged from 35 to 75 years old.Tumor inva-sion into peripheral thyroid tissue was observed in 2 cases.Immunohistochemical analysis revealed positive expression for CD5,CD117,p63,p40,CK5/6,CK17 and CKpan,with focal positivity for Syn observed in only 1 case.Genetic testing:1 patient had mutations in the TERT promoter gene(C.-228 C＞T).Conclusion ITC is an extremely rare,low-grade malignant tumor.Due to its morphological similarity to other highly malignant thyroid tumors,it is prone to misdiagnosis.Immunohistochemistry and genetic testing play a crucial role in accurate differential diagnosis.
