Advances in proteomic technologies for asthenozoospermia
10.3760/cma.j.cn101441-20220420-00172
- VernacularTitle:蛋白质组学技术在弱精子症中的应用进展
- Author:
Yan ZHANG
1
;
Liangzhao LIU
1
;
Han LIU
1
;
Yonghua HE
1
;
Chaoyan OU
1
Author Information
1. 桂林医学院公共卫生学院，桂林 541001
- Publication Type:Journal Article
- Keywords:
Asthenozoospermia;
Proteomics;
Electrophoresis, gel, two-dimensional;
Yeast two-hybrid;
Chromatography;
Mass spectrum;
Bioinformatics;
Mechanisms of occurren
- From:
Chinese Journal of Reproduction and Contraception
2023;43(4):432-437
- CountryChina
- Language:Chinese
-
Abstract:
Asthenozoospermia is a condition of deficient motility of spermatozoa, and about 27.8% of male infertility results from asthenozoospermia. Its etiology is complex and its pathogenesis is still unclear, and exploring its pathogenesis can help to find effective prevention and treatment strategies. In recent years, with the development of proteomic technologies (two-dimensional electrophoresis, yeast two-hybrid technology, mass spectrum, etc.), many researchers have focused their researches on the study of asthenozoospermia based on proteomics, revealing the differential proteins of asthenozoospermia and the biological pathways that underlie them, providing numerous theoretical support for the mechanistic study of asthenozoospermia. In this review, we focus on the relevant techniques of proteomics and summarize the many achievements made in understanding the differential protein expression, etiology, and mechanism of asthenozoospermia, which will hopefully provide new insights into the diagnosis and treatment of asthenozoospermia. Protein-protein interactions and pathways and metabolic abnormalities provide a promising direction to study sperm motility in asthenozoospermia.
