Research progress on role of tRNA-derived small RNA in neuropsychiatric disorders
- VernacularTitle:tRNA来源的小RNA在神经精神疾病中的作用研究进展
- Author:
Shuai CHU
1
;
Ting-ting WU
;
Qing-xiao HONG
;
Wei-sheng CHEN
;
Wen-hua ZHOU
;
Hui-fen LIU
;
Hai-hang YU
Author Information
- Publication Type:Journal Article
- Keywords: transfer-RNA derived small RNA; tRNA-derived stress-induced RNA; tRNA-derived fragment; neuropsychiatric disease; gene regulation; biomarkers
- From: Chinese Pharmacological Bulletin 2025;41(2):219-225
- CountryChina
- Language:Chinese
- Abstract: Transfer-RNA derived small RNA(tsRNA),a re-cently discovered class of non-coding RNA,is produced by ma-ture tRNA or tRNA precursor through the mediation of specific endonucleases.By regulating gene expression at the transcrip-tional and post transcriptional levels and acting as an epigenetic regulator,tsRNA plays an important role in the physiological and pathological processes of many organisms.Therefore,it has gradually become a research hotspot in biomedicine and attracted widespread attention.Moreover,there is increasing evidence that tsRNA is involved in the occurrence and development of many neuropsychiatric diseases through participating in stress re-sponse,cell proliferation and apoptosis,neural development,synaptic plasticity,neuroinflammation and immune regulation,epigenetic regulation,RNA processing,and protein translation regulation.This article mainly discusses the generation,classifi-cation and biological functions of tsRNA,and elaborates on the role and possible mechanisms of tsRNA in neurodevelopment and neuropsychiatric disorders,thereby further revealing the poten-tial of tsRNA as a reliable biomarker and therapeutic target for neuropsychiatric disorders.
