Advances in Role of Intestinal Immune Microenvironment in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2024.06.009
- VernacularTitle:肠道免疫微环境在炎症性肠病中作用的研究进展
- Author:
Dingwei ZHEN
1
;
Tong LIU
;
Shanyu GAO
Author Information
1. 山东中医药大学第一临床医学院(250355)
- Publication Type:Journal Article
- Keywords:
Immune Microenvironment;
Colitis,Ulcerative;
Crohn Disease;
Immune Cells;
Cytokines
- From:
Chinese Journal of Gastroenterology
2024;29(6):370-375
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a group of chronic autoimmune inflammatory disorder that attack the gastrointestinal tract,mainly categorized into two types:ulcerative colitis and Crohn′s disease.Studies have shown that the pathogenesis of IBD is complex,involving genetic,microbial,immune response,and environmental factors.Among them,the abnormal activation of the immune system,including immune cells,cytokines,and cell-to-cell interactions,as well as the alterations of the immune microenvironment,play a key role in the pathogenesis of IBD.This article reviewed the regulatory role and mechanism of immune microenvironmental changes in IBD,with the aim of providing new ideas and research direction for the formulation of immunotherapy regimens for IBD.
