Research progress of abnormal erythrocytes and Alzheimer disease
10.3969/j.issn.1002-0152.2025.07.007
- VernacularTitle:红细胞异常与阿尔茨海默病的研究进展
- Author:
Yao MENG
1
;
Wei ZHANG
Author Information
1. 首都医科大学附属北京天坛医院神经病学中心(北京 100070)
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Erythrocytes;
Cognitive function;
Biomarkers;
Brain structural;
Therapy
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(7):426-431
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease(AD)is the most common type of cognitive impairment,but its current diagnostic methods have limitations.Increasing studies have shown that the erythrocytes are abnormal in AD patients at different stages.Therefore,this article reviews the changes of erythrocytes and their relationships with disease stage,clinical symptoms,and biomarkers of AD and red blood cell-targeted therapies.Studies have indicated that AD patients have significant changes in the quantity,morphology,and physical characteristics of erythrocytes,which are related to cognitive level,AD biomarkers,and brain structural changes.These changes can predict AD risk,identify AD occurrence,and evaluate disease severity.Dietary supplementation by targeting erythrocytes may prevent AD occurrence and improve the cognitive function of patients.This review presents the progress of erythrocyte changes in the diagnosis and treatment of AD,aiming to bring new perspectives to the early diagnosis and treatment of AD.
