Comparative Analysis of Tumor Biological Behaviors Between Pure Gastric Signet-ring Cell Carcinoma and Mixed Gastric Signet-ring Cell Carcinoma Based on Pathology
10.3969/j.issn.1008-7125.2024.06.002
- VernacularTitle:基于病理的胃纯印戒细胞癌与胃混合印戒细胞癌肿瘤生物学行为对比分析
- Author:
Jiaohua CHEN
1
;
Sibiao SU
Author Information
1. 广西医科大学(530021)
- Publication Type:Journal Article
- Keywords:
Pure Gastric Signet-Ring Cell Carcinoma;
Mixed Gastric Signet-Ring Cell Carcinoma;
Stomach Neoplasms;
Biological Behaviors;
Prognosis
- From:
Chinese Journal of Gastroenterology
2024;29(6):325-333
- CountryChina
- Language:Chinese
-
Abstract:
Background:The tumor biological behaviors of pure gastric signet-ring cell carcinoma(pGSRC)and mixed gastric signet-ring cell carcinoma(mGSRC)have not been comprehensively investigated,and the differences between the two subtypes remain undetermined.Aims:To compare the tumor biological behaviors of pGSRC and mGSRC,in order to provide reference for the individualized and precise treatment of gastric cancer.Methods:A total of 255 patients with gastric signet-ring cell carcinoma(GSRC)who underwent radical surgical resection from December 2012 to June 2023 at the First Affiliated Hospital of Guangxi Medical University were enrolled.The tumor biological behaviors of pGSRC and mGSRC were compared.Survival analysis was performed using Kaplan-Meier method.Univariate and multivariate Cox proportional hazards model was used to identify prognostic factors for GSRC,as well as for pGSRC and mGSRC separately.Results:Compared with pGSRC,mGSRC was associated with significantly higher rates of vascular invasion(37.3%vs.24.8%,P=0.034)and lymph node metastasis(59.3%vs.42.9%,P=0.010),the proportions of patients with T1 infiltration depth(28.0%vs.45.7%,P=0.004)and TNM stage Ⅰ(30.0%vs.51.4%,P=0.003)were significantly decreased.Kaplan-Meier survival analysis showed that the 5-year survival rate of pGSRC patients was significantly higher than that of mGSRC patients(90.4%vs.76.2%,P=0.003).Multivariate Cox proportional hazards model analysis identified male gender,CA19-9,tumor diameter,TNM stage Ⅲ,and mixed pathological type as independent risk factors for poor prognosis in GSRC patients after radical surgery(P<0.05).Alcohol consumption history was an independent poor prognostic factor for pGSRC(P<0.05).Male gender,CA19-9,tumor diameter,and TNM stage Ⅲ were independent poor prognostic factors for mGSRC(P<0.05).Conclusions:Compared with pGSRC,mGSRC exhibits more aggressive biological behaviors.It is more likely to experience vascular invasion and lymph node metastasis,more advanced TNM stage,deeper infiltration depth and a relatively lower 5-year survival rate.Furthermore,mGSRC is an independent risk factor for poor prognosis after radical surgery.
